Pefloxacin penetration into human necrotic pancreatic tissue

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Pefloxacin penetration into human necrotic pancreatic tissue.

Antibiotic prophylaxis may be useful in acute necrotising pancreatis, a disease associated with a considerable incidence of infectious complications. The aim of this study was to assess pefloxacin penetration into necrotic pancreatic tissue during human necrotic pancreatitis. Ten patients (mean age 53.2 +/- 17.4 years) with severe acute pancreatitis (mean Ranson score 4.3) were studied. Pefloxa...

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The aim of the study was to verify whether antibiotics excreted by the normal pancreas are also excreted in human necrotizing pancreatitis, reaching the tissue sites of the infection. Twelve patients suffering from acute necrotizing pancreatitis were treated with imipenem-cilastatin (0.5 g), mezlocillin (2 g), gentamicin (0.08 g), amikacin (0.5 g), pefloxacin (0.4 g), and metronidazole (0.5 g)....

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 1996

ISSN: 0305-7453,1460-2091

DOI: 10.1093/jac/38.2.237